Serous effusions: diagnosis of malignancy beyond cytomorphology. An analytic review.
نویسندگان
چکیده
In this brief review, the role of various ancillary techniques to detect malignancy in effusion fluid are evaluated and discussed. The data were collected from a large number of research articles published in various medical journals. The role of these techniques to increase the diagnostic accuracy in serous effusions is emphasised.
منابع مشابه
Use of antisera to epithelial membrane antigen for the cytodiagnosis of malignancy in serous effusions.
A new human antigen, designated epithelial membrane antigen (EMA), has recently been described on surface membranes of a wide variety of normal epithelium but not on connective tissue cells. The antigen is only weakly expressed on normal or reactive mesothelium. Increased expression of the antigen has been observed in most neoplasms of epithelial origin and in malignant mesothelioma. We have in...
متن کاملIdentification of Malignant Cells in Serous Fluids Using a Panel of Monoclonal Cytokeratin Antibodies, Epithelial Membrane Antigen(EMA) , Carcino Embryonic Antigen (CEA)
Abstract Background and Objective: Identification of malignant cells and the type of malignancy in Effusionsis very important. The main aim of this study was to differentiate between reactive mesothelial cells and malignant cells and to determine the type of the tumor cells in effusions with the aid of tumor markers Creatine Kinase (CK), EMA and CEA. Material and Methods: Forty serous flui...
متن کاملThe role of argyrophilic nucleolar organizer region (AgNoR) study in cytological evalution of fluids, especially for detection of malignancy.
BACKGROUND Serous effusion smears reported as (suspicious for malignancy) pose problems in clinical management. Silver staining for argyrophilic nucleolar organizer regions (AgNOR) has proved useful in making a cytopathologic differential diagnosis between benign and malignant cells. Nucleolar organizer regions(NORs) are loops of DNA located in acrocentric chromosomes. These NORs are visualized...
متن کاملPleural fluid cytology in suspected malignant effusions with special emphasis on cell block preparation
Background: Cytlogical examinations of serous effusions have been well accepted and a positive diagnosis often considered as definitive diagnosis. It helps for staging and prognosis of the patients for malignancy. Accurately diagnosing cells as being either malignant or benign reactive mesothelial cells in serous effusions is a common diagnostic problem in conventional cytological smears (CS). ...
متن کاملEvaluation of a panel of molecular markers for the diagnosis of malignant serous effusions.
PURPOSE Our main goal was to evaluate a panel of molecular markers for the detection of cancer cells in serous effusions and to determine their value as an adjunctive reverse transcription-PCR (RT-PCR) test to cytologic examination. EXPERIMENTAL DESIGN One hundred fourteen serous effusions from 71 patients with tumors and 43 patients with benign diseases were subjected to RT-PCR for expressio...
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عنوان ژورنال:
- Postgraduate medical journal
دوره 79 936 شماره
صفحات -
تاریخ انتشار 2003